Sixteen Vietnamese people were arrested in raids, while dozens of mobile phones, ATM cards and SIM cards were also seized.
The report did not say what has happened to the huge sums of money made by the site, which was deactivated on Friday.
“I lost so much money playing games on this site. You might win at first, but the more you play, the more you lose,” a player told AFP, requesting not to be named.
Vietnam’s communist government has recently started loosening its grip on domestic gambling, allowing Vietnamese to bet in casinos on a trial basis and opening up some sports betting.
However online gambling and private card rooms are banned.
Still, illegal gambling run by both locals and foreigners flourishes.
In July last year, more than 380 Chinese were arrested for taking online wagers from Chinese punters on sports and running an illegal lottery in the country.
And in January this year four people were shot dead at an illegal cockfighting betting ring in southern Vietnam, state media reported, a rare gun homicide in the communist country.